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Li Group Software

The following software packages and utilities can be downloaded freely. If you find them useful, please email me: yunli@med.unc.edu. Comments and suggestions are welcome!

Software    Database    Utilities   

Software

  • AbCD Arbitrary Coverage Design for Sequencing-based Studies
  • BETASEQ Data Correction in Unbalanced Sequencing Studies for Valid Rare Variant Association Testing
  • EMLRT Post-Imputation Association Analysis using EM Likelihood Ratio Tests (LRT)
  • DISSCO Direct Imputation of Summary Statistics allowing COvariates
  • HUGIN Hi-C Unifying Genomic INterrogator - Web-based viewer of Hi-C across 21 different cells and tissue data with genomic information
  • KARMA K-tuple Alignment with Rapid Matching Algorithm
  • MaCH MArkov Chain Haplotyping: rapid haplotyping and genotype imputation (wiki)
  • MaCH-Admix Genotype Imputation for Admixed Populations or with Large Reference Panels
  • mach2dat Imputation-based analysis of binary traits (windows version) (How-To-Use-The-Windows-Command-Line)
  • mach2qtl Imputation-based analysis of quantitative traits (windows version) (How-To-Use-The-Windows-Command-Line)
  • SAFE-clustering Single-cell Aggregated (From Ensemble) Clustering for Single-cell RNA-seq Data
  • ShotGun a flexible short read simulator
  • thunder LD-based genotype caller and haplotyper on massively parallel sequencing data (wiki)
  • UNCcombo Likelihood based association testing for next generation sequencing data without intermediate genotype calling
  • WHaIT Weighted Haplotype and Imputation dosage Tests for rare variants association

Database


Utilities

  • CalcMatch Concordance between two sets of genotype data (wiki)
  • changePedStrand Change Strand (by base pairing) for a Pedigree file
  • Concatenate Haplotypes Concatenate Two Sets of Haplotypes
  • doseR2 Dosage r2 Calculator
  • dose2geno Generate Best Guess Genotypes from Dosage and Info File
  • ExtractImputed Extract information for a subset of sites from imputed dataset
  • flipDosages Flip Dosages (to obtain consistent AL1/AL2 coding across multiple dosage files)
  • g2h.pl Convert genotypes (in .ped format) to haplotypes
  • h2g.pl Convert haplotypes to genotypes (in .ped format)
  • h2h.pl Extract haplotypes for a subset of markers
  • haploxt LD Calculator from Phased Haplotypes (wiki)
  • Ligate Haplotypes Ligate Haplotypes with Two Overlapping Regions
  • prob2dose Converts MaCH/MaCH-admix prob output to MaCH/MaCH-admix dose output
  • prob2plink Converts MaCH/MaCH-admix prob+info output to PLINK dosage file
  • ped2numeric Convert QTDT pedigree file into 012 coding (dosage) file
  • r2_hat Calculate Imputation Quality Estimate (r2_hat) from dosage data
  • RegionalHapMapExtractor Extract a Region from HapMapII for MaCH/MaCH-admix imputation
  • splitPed Splits a pedigree file into smaller files with subsets of markers (wiki)
  • splitRef Splits a reference haplotype file into smaller files with subsets of markers (wiki)