FIREcaller: an R package for detecting frequently interacting regions from Hi-C data

Getting Start with FIREcaller

To get started, the R package can be downloaded from here, and be installed from the unzipped file following the command:
   install.packages("local_path/FIREcaller/", repos = NULL, type = "sources")

Or it can be directly installed from GitHub yycunc/FIREcaller following the instruction.

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Guided Analyses

In this tutorial, we will analyze Hippocampus dataset from Schmitt et al. (Cell Reports, 2016), which contains Hi-C contact matrix of 22 autosomes from human Hippocampus. Hi-C input files and the mappability file can be downloaded from DOWNLOAD webpage.

A guided walkthrough of this analysis is provided by R markdown tutorial.